Genetic Methylation Test

1. APOE Status: Apolipoprotein E (ApoE) is a lipid-binding protein that transports triglycerides and cholesterol in multiple tissues, including the brain. The e4 allele is common in hunter-gatherer communities, while the e3 and e2 alleles are most common in agricultural communities.

2. Protein Requirements: Traditional protein intake ranges based on latitude from less than 18% of total calories to approximately 35% in the far northern climates. Recommended protein intake varies based on weight and exercise intensity.

3. Carbohydrate Requirement: Your carbohydrate intake range is based on the latitude of your ancestors and whether a hunter-gatherer diet or modern agricultural diet made a larger imprint on your genes. The dierences between responses in individuals to rened carbohydrates have been linked to a genetic adaptation occurring during the agricultural age.

4. Fat Requirements: The NIH has set the recommended intake of omega-3's from 1.1 to 1.6 grams per day from a combination of ALA, EPA and DHA. Omega-3 fatty acids are essential for brain, eye, and cardiovascular health. Traditional total fat intake ranges based on latitude, with as low at 25% consumed in countries closer to the equator, and up to 55% of total calories from fat being consumed in northern latitudes. The 2020 Dietary Guidelines in the U.S. recommends limiting calories from saturated fats to less than 10% of the total calories you eat and drink each day. That’s about 200 calories for a 2,000 calorie diet. Traditionally, saturated fat intake from animal foods ranged based on the season and the geographical location, with higher latitudes and more mountainous regions consuming more.

5. Celiac Disease: Celiac disease is an immune reaction to eating gluten, a protein found in wheat, barley and rye. Published research shows that approximately 30 percent of the general population have variants in the celiac disease risk genes HLA-DQA1 through HLA-DQB, yet only 3% of these individuals develop celiac disease

6. Micronutrients: B1, B2, B3, B6, B9, B12, Boron, Choline & Betaine, Vitamin A, Vitamin D, Vitamin C, Vitamin E, Vitamin K2, Magnesium, Manganese, Lithium, Potassium, Iron, Selenium, Zinc, Copper

7. Fiber Requirements: The recommended amount of ber is up to 25 grams per day for women and up to 38 grams per day for men.

8. Phytonutrient Requirements: Phytoestrogens, Lutein & Zeaxanthin, Polyphenols, Cinnamon, Cruciferous Vegetables, Lycopene, Apigenin, Resveratrol.

9. Lactose Tolerance: Lactose is the major carbohydrate in milk. The arrival of farming in Europe around 8,500 years ago necessitated adaptation to new environments, pathogens, diets, and social organizations. One of the best examples of genetic dietary changes to this is the lactase enzyme in northern Europeans that only dates to the last 4,000 years

10. Caffeine Metabolism: Variants in the CYP1A2 gene determine the rate at which you metabolize caffeine.

Methylation is a crucial biochemical process involving the addition of a methyl group (CH₃) to DNA, proteins, and other molecules. This process relies on the MTHFR, MTR, MTRR, COMT and ACHy genes working optimally, which is all discussed in your report. Additionally, key nutrients are required for this process:

1. Folate: MTHFR 677 and MTHFR 1298 genotypes determine your folate requirements to assist normal homocysteine levels.

2. Folinic Acid: Folinic acid is a second type of folate found in folate-rich food.

3. Vitamin B6: Vitamin B6 plays an important role in homocysteine metabolism and CBS gene function.

4. Vitamin B12: Vitamin B12 plays an important role in homocysteine metabolism.

5. Riboflavin (B2): Vitamin B2 plays a special role in stabilizing the MTHFR gene for homocysteine metabolism.

6. Choline and Betaine: Choline and betaine play a crucial role in homocysteine metabolism, especially for those with variants in MTHFR.

7. Synthetic Folic Acid: Certain genotypes in the folate metabolism pathway can affect the metabolism of synthetic folic acid, leading to high circulating levels.

1. Breat Protection: Certain glutathione SNPs are associated with breast protection.

2. Estrogen Detoxification: There are multiple genes in the estrogen detoxication pathway that have a cumulative value on the ability to properly detoxify estrogen.

3. Prostate Protection: Numerous gene combinations are required to determine a cumulative value of prostate protection

4. Oxidative Stress and Fertility: Pesticides, cadmium, mercury, and arsenic have all been shown to lower GSTP1 expression, increasing the elevation and toxicity of these chemicals and heavy metals. The exposure and sensitivity to these chemicals and heavy metals are suspected reasons for the increased risk of male infertility related to GSTP1 variants.

5. T3 & T4: T3 and T4 level variations have been associated with variants in the DI01 gene

6. Adiponectin: ADIPOQ encodes for adiponectin, a protein secreted by fat cells that aect insulin and glucose metabolism. Low levels of adiponectin play a role in obesity, insulin resistance and Type 2 diabetes.

7. Ghrelin: Variants in genes related to ghrelin levels and dopamine receptor density have been shown to create a larger appetite and the potential for overeating in multiple populations.

1. Brain Repair & Maintenance: Multiple genes are responsible for daily neural repair and maintenance, and a combination of genotypes are associated with decreased neural repair

2. Concussion Recovery: A combination of genotypes in the pathways responsible for glutamate transport and modulation, BDNF levels, neural repair, and inammation during a concussion are associated with delayed or improved recovery.

3. Episodic Memory: The 5-HT2A gene is associated with episodic memory, which is the ability to recall details of an event.

4. Cardio, Mood & Cognitive Fitness: Cardiovascular exercise has a tremendous inuence on neurotransmitter balance, memory and cognitive tness

5. Mood (Folate): MTHFR genotypes determine folate requirements for healthy BH4 levels responsible for neurotransmitter balance. The current daily value for folate is 400mcg DFE.

6. Anxiety (Choline): The PEMT gene is associated with your required choline intake to support memory, anxiety and REM sleep.

7. Anxiety (Glutamate & GABA): Anxiety is linked to altered levels of one or multiple neurotransmitters. Understanding the genetic link to specic levels of neurotransmitters can help you be precise in your approach to reduce anxiety.

8. Fear Response: The FAAH gene is associated with anandamide levels, correlated with a heightened fear response to potential threats, while BDNF variants aect the ability to extinguish the fear response.

9. Addiction: ANKK1 modulates the density of dopamine receptors in the brain and is the most-studied genetic variant related to addictions. Variants have been associated with alcoholism, opioid addiction, sugar addictions, compulsive eating, obesity and Internet addiction.

10. Reward System: COMT rs4680 has been linked in a meta-analysis to variations in the reward response based on genotypes associated with low and high dopamine levels.

11. COMT Genotype (Pressure Response): Your COMT genotype is associated with the "Hybrid" that has intermediate to high levels of dopamine and may be able to express the Warrior or Strategist traits depending on life experience. Higher dopamine is useful in complex environments that require maximal performance in terms of memory and attention for survival.

12. Sleep Support: Recommended Wake Time, Caffeine Sleep Disturbance, REM Sleep.

13. Stress Management: Stress Perception, Stress & Digestion, Cario & Stress Relief, Weight Training & Stress Relief.

1. Toxin Sensitivity: Mycotoxins, Xenoestrogens, Occupational Toxins, Ethanol, Formaldehyde, Benzo(a)pyrene, Aromatic Amines, Benzene, Aspartame, Food Dyes.

2. Pesticides, Herbicides and Heavy Metal Sensitivity: Glyphosate, Organochlorines, Organophosphate Insecticides, Arsenic, Cadmium, Mecury, Lead.

1. Bacteria, Yeast, Parasites and Viruses: H. Pylori, Candida, Malaria, Norovirus, DNA Viruses.

2. Covid-19: SARS-CoV02 Susceptibility, COVID-19 Viral Severity, COVID-19 Lung Damage Severity, Glutahione. Vitamin A, Vitamin C, Vitamin D, Selenium, Zinc, Copper, Iron, B12, Folate, B6, Bifidobacteria, Glycine.

Glutathione Protection, Catalase Protection, Mitochondrial Protection, UV Protection, Skin Protection, Lung Protection, Colon Protection, Cured Meat and Colon Health, Eye Protection, Thyroid Protection, Pancreas Protection, Bladder Protection.

1. Cardiovascular Health: HDL and LDL, VLDL, Triglycerides, SpoB, Lp(a), Raw Plant Intake, Nitric Oxide, Homocysteine, High Blood Pressure, Blood Clots, Uric Acid, Fibrinogen, Hemochromatosis.

2. Exercise: Power Athele Ptential, Weight Lifting Inflammation, Endurance Exercise Inflammation, High-Intensity Exercise Inflammation, ACL and Shoulder Dislocation Risk, Ankle and Hamstring Injury Risk, Cold Endurance, VO2 Max Trainability, Caffeine Response for Exercise Under 1 Hour, Caffeine Reponse for Exercise Over 1 hour.